Chi Site At Biology Glossary

What is it? An 8-nucleotide DNA sequence (5 GCTGGTGG 3) which is a hot-spot for homologous recombination. When the RecBCD exonuclease encounters a chi site the RecD subunit is released and the RecBC complex then functions as a helicase, unwinding the DNA and providing single stranded which can invade a homologous region of double-stranded DNA. Chi sites typically occur about once every 5 kb on the chromosomes of enteric bacteria and most are oriented in the same direction as DNA replication.

Bio Definition Added By: Marissa

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