P53 At Biology Glossary

What is it? A 53KDa protein the product of a tumour suppressor gene. The loss of this protein due to mutation is a primary event in the formation of many types of cancer (breast, colon, lung, leukaemia, liver). P53 is involved in regulating the activity of some other genes (eg. P21, a cell division kinase inhibitor). It also prevents cells entering cell division. P53 levels are increased after DNA is damaged by UV and ionizing radiation and cells are arrested in cell division until either the damage is repaired or they die by apoptosis (programmed cell death).

Bio Definition Added By: Luke

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